Outbreaks in Distinct Regions Due to a Single Klebsiella pneumoniae Clone Carrying a bla VIM-1 Metallo-β-Lactamase Gene
ABSTRACT From December 2004 to March 2005, 27 Klebsiella pneumoniae clinical isolates that were positive by the imipenem-EDTA double-disk synergy test and that exhibited a single macrorestriction pattern were recovered in two distinct Greek hospitals. The isolates carried a transferable bla VIM-1 me...
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Published in | Journal of clinical microbiology Vol. 43; no. 10; pp. 5344 - 5347 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
01.10.2005
|
Online Access | Get full text |
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Summary: | ABSTRACT
From December 2004 to March 2005, 27
Klebsiella pneumoniae
clinical isolates that were positive by the imipenem-EDTA double-disk synergy test and that exhibited a single macrorestriction pattern were recovered in two distinct Greek hospitals. The isolates carried a transferable
bla
VIM-1
metallo-β-lactamase gene in a class 1 integron. Reverse transcriptase PCR showed that the gene was similarly expressed in low- and high-level carbapenem-resistant isolates, indicating the existence of additional resistance mechanisms. The clonal spread of VIM-1-producing
K. pneumoniae
strains in distinct regions where up to now
bla
VIM-2
and
bla
VIM-4
alleles were common is worrisome. |
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ISSN: | 0095-1137 1098-660X |
DOI: | 10.1128/JCM.43.10.5344-5347.2005 |