Stereospecific synthesis of a GS 4104 metabolite: Determination of absolute sterochemistry and influenza neuraminidase inhibitory activity

• Published in: Bioorganic & medicinal chemistry letters Vol. 9; no. 19; pp. 2811 - 2814
• Main Authors: Lew, Willard, Escarpe, Paul A., Mendel, Dirk B., Sweeny, David J., Kim, Choung U.
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.10.1999

The total synthesis for the determination of the absolute stereochemistry of a GS 4104 metabolite 3 is described. In addition, the influenza neuraminidase inhibitory activity of 3 and related intermediates are reported. The total synthesis for the determination of the absolute stereochemistry of a G...