Stereospecific synthesis of a GS 4104 metabolite: Determination of absolute sterochemistry and influenza neuraminidase inhibitory activity

The total synthesis for the determination of the absolute stereochemistry of a GS 4104 metabolite 3 is described. In addition, the influenza neuraminidase inhibitory activity of 3 and related intermediates are reported. The total synthesis for the determination of the absolute stereochemistry of a G...

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Bibliographic Details
Published inBioorganic & medicinal chemistry letters Vol. 9; no. 19; pp. 2811 - 2814
Main Authors Lew, Willard, Escarpe, Paul A., Mendel, Dirk B., Sweeny, David J., Kim, Choung U.
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.10.1999
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Summary:The total synthesis for the determination of the absolute stereochemistry of a GS 4104 metabolite 3 is described. In addition, the influenza neuraminidase inhibitory activity of 3 and related intermediates are reported. The total synthesis for the determination of the absolute stereochemistry of a GS 4104 metabolite 3 is described. In addition, the influenza neuraminidase inhibitory activity of 3 and related intermediates are reported.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(99)00479-5