Cognitive impairment and compliance in chronic heart failure

• Published in: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova Vol. 117; no. 6. Vyp. 2; p. 53
• Main Authors: Shestakova, M V, Vasilenko, A F, Karpova, M I, Grigoricheva, E A, Epaneshnikova, N V, Kochetkov, I V
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2017
• Subjects: chronic heart failure; cognitive impairment; ejection fraction; compliance
• ISSN: 1997-7298
• DOI: 10.17116/jnevro20171176253-57

To determine the factors of cognitive impairment and non-compliance in patients with chronic heart failure (CHF). One hundred and fifty-seven patients with CHF and 32 patients without chronic heart failure (controls) were examined. Neuropsychological assessment using a 30-minutes protocol recommended by NINDS-Canadian Stroke Standards (NINDS CSS), magnetic resonance imaging, cognitive ERP and a test of compliance were used. Approximately 62% of patients did not perform medical prescriptions. Non-compliance was associated with an increase in the severity of subcortical and perivenricular leukoaraiosis, a slowdown in decision-making processes (an increase in the P300 latency), worse performance on speech activity tests, optical/spatial and frontal dysfunctions and memory. Patients with non-compliance had frontal cognitive impairment (58%), memory impairment (40%) and mixed forms (21%). Cognitive impairment in patients with chronic heart failure was associated with the lower left ventricular ejection fraction and deterioration in indices of diastolic function.