Molecular medicine-based IBD treatment strategies—we take it personally

• Published in: Frontiers in gastroenterology (Lausanne, Switzerland) Vol. 2
• Main Authors: Hentschel, Viktoria, Klaus, Jochen
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 09.08.2023
• Subjects: biomarker; Crohn’s disease; personalized medicine (PM); prediction of response to therapy; ulcerative colitis
• ISSN: 2813-1169; 2813-1169
• DOI: 10.3389/fgstr.2023.1226048

In light of potentially aggressive disease courses of either IBD type—CD or UC—marked by frequent flareups or non-subsiding inflammatory activity, effective immunosuppression is key to preventing progressive tissue destruction and permanent disability. However, over-treating patients with a high probability of an indolent disease course ought to be avoided. To solve this therapeutic dichotomy, there is a pressing need for a reliable classification of patients based on their biosignature to rate their individual prognosis and likelihood of response to a given therapy. This need for pinpoint therapeutic strategies is addressed by the concepts of PreM and the more stringently defined PerM. In this review we summarize the most pivotal study results published so far in the field of individualized IBD care with a special focus on molecular diagnostics and their applicability in the clinical setting.