Polysaccharide-based hydrogels for cartilage regeneration

Cartilage defect is one of the common tissue defect clinical diseases and may finally lead to osteoarthritis (OA) which threat patients’ physical and psychological health. Polysaccharide is the main component of extracellular matrix (ECM) in cartilage tissue. In the past decades, polysaccharide-base...

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Published inFrontiers in cell and developmental biology Vol. 12
Main Authors Chen, Ning, Li, Sidi, Miao, Congrui, Zhao, Qin, Dong, Jinlei, Li, Lianxin, Li, Ci
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 11.10.2024
Subjects
3D bioprinting
biomaterials
cartilage regeneration
hydrogels
polysaccharide
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Summary:Cartilage defect is one of the common tissue defect clinical diseases and may finally lead to osteoarthritis (OA) which threat patients’ physical and psychological health. Polysaccharide is the main component of extracellular matrix (ECM) in cartilage tissue. In the past decades, polysaccharide-based hydrogels have shown great potential for cartilage regeneration considering unique qualities such as biocompatibility, enhanced cell proliferation, drug delivery, low toxicity, and many others. Structures such as chain length and chain branching make polysaccharides have different physical and chemical properties. In this review, cartilage diseases and current treatment options of polysaccharide-based hydrogels for cartilage defection repair were illustrated. We focus on how components and structures of recently developed materials affect the performance. The challenges and perspectives for polysaccharide-based hydrogels in cartilage repair and regeneration were also discussed in depth.
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2024.1444358