Biochemical markers predicting response to radiation- and radiochemo-therapy in cancer patients

In last years there is increasing interest in radiogenomics and the characterization of DNA array molecular profiles that can predict tumor and no tumor tissues radioresponse. Ongoing studies carried out worldwide in the banking of tumor and no tumor samples give evidence that perspective markers fo...

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Bibliographic Details
Published inBiomeditsinskaia khimiia Vol. 58; no. 6; p. 635
Main Author Ivanov, S D
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.11.2012
Subjects
Apoptosis - drug effects
Apoptosis - genetics
Apoptosis - radiation effects
Biomarkers - analysis
Biomarkers, Tumor - analysis
Gene Expression Regulation, Neoplastic
Humans
Neoplasms - drug therapy
Neoplasms - genetics
Neoplasms - pathology
Neoplasms - radiotherapy
Polymorphism, Single Nucleotide
Predictive Value of Tests
Prognosis
Treatment Outcome
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Summary:In last years there is increasing interest in radiogenomics and the characterization of DNA array molecular profiles that can predict tumor and no tumor tissues radioresponse. Ongoing studies carried out worldwide in the banking of tumor and no tumor samples give evidence that perspective markers for response prediction in individual patient to intended radiation therapy can be some apoptotic indexes, spectrum a number of specific proteins, and DNA-based microarray molecular profiling analysis as well determination of single nucleotide polymorphisms in genome of the patients. So far there are only a few robust reports of molecular markers predicting tumor and no tumor tissues response to radiation. The results of new studies, which in future should be validated in larger definitive trials, are likely to see in nearest years. It is needed to determine technologies of methods and to define more precisely areas of its applications.
ISSN:2310-6972
DOI:10.18097/pbmc20125806635