Phosphorylation of Histones in Cells Treated with Hypertonic and Acidic Media

Factors in the extracellular environment, specifically hypertonic or acidic growth media, are shown to alter the modification of histones in several cell lines. For histone 2A, changes in modification were visible in the mass pattern and were found to be primarily changes in phosphorylation. The inc...

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Bibliographic Details
Published inMolecular and cellular biology Vol. 4; no. 6; pp. 1186 - 1188
Main Authors Pantazis, Panagiotis, West, Michael H. P., Bonner, William M.
Format Journal Article
LanguageEnglish
Published Taylor & Francis 01.06.1984
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Summary:Factors in the extracellular environment, specifically hypertonic or acidic growth media, are shown to alter the modification of histones in several cell lines. For histone 2A, changes in modification were visible in the mass pattern and were found to be primarily changes in phosphorylation. The increased modification of the core histones was quickly reversed when cells were returned to normal medium.
ISSN:1098-5549
1098-5549
DOI:10.1128/mcb.4.6.1186-1188.1984