Lipid nanoparticle and polyplex nanomicelle for mRNA delivery

Lipid nanoparticles（LNPs）, which are a typical DDS used in mRNA vaccines, and polyplex nanomicelles that can deliver mRNA without causing inflammation at the administration site, are evaluated using the same mRNA under the same conditions. LNP yielded high levels of protein expression with inflammat...

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Bibliographic Details
Published inDrug Delivery System Vol. 39; no. 5; pp. 362 - 366
Main Authors Itaka, Keiji, Xuan, Du
Format Journal Article
LanguageJapanese
Published Kawasaki THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM 25.11.2024
Japan Science and Technology Agency
Subjects
Drug development
Hydrodynamic limb vein (HLV) injection
Inflammation
Injection
Lipid nanoparticle (LNP)
Lipids
mRNA
mRNA medicine
mRNA vaccine
Nanoparticles
Polyplex nanomicelle
Proteins
Online AccessGet full text
ISSN0913-5006
1881-2732
DOI10.2745/dds.39.362

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Summary:Lipid nanoparticles（LNPs）, which are a typical DDS used in mRNA vaccines, and polyplex nanomicelles that can deliver mRNA without causing inflammation at the administration site, are evaluated using the same mRNA under the same conditions. LNP yielded high levels of protein expression with inflammation at the injection site. In contrast, nanomicelles provided less but sustained protein production, with almost no inflammation at the injection site. It is important to have a variety of DDS options, which would be suitable for various purposes and administration route, for future mRNA drug development.
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ISSN:0913-5006
1881-2732
DOI:10.2745/dds.39.362