Biodistribution and imaging of 99mTc-MAVGG-adenine in tumor bearing mice

To increase the tumor uptake of Val-Gly-Gly (VGG), adenine was introduced into the peptide. N-mercaptoacetyl-VGG-adenine (MAVGGadenine) and MAVGG were labeled with 99mTc using a solution of SnCl2 and tartaric acid as reducing agent. Biodistribution in mice bearing the S180 tumor was measured and y i...

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Published inJournal of radioanalytical and nuclear chemistry Vol. 273; no. 1; pp. 25 - 29
Main Authors Zhang, C L, Zhao, Y L, Feng, S J, Qi, C M, Fu, Z L, Guo, F G, Wang, R F
Format Journal Article
LanguageEnglish
Published 01.07.2007
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Summary:To increase the tumor uptake of Val-Gly-Gly (VGG), adenine was introduced into the peptide. N-mercaptoacetyl-VGG-adenine (MAVGGadenine) and MAVGG were labeled with 99mTc using a solution of SnCl2 and tartaric acid as reducing agent. Biodistribution in mice bearing the S180 tumor was measured and y imaging was performed. Compared with MAVGG, adenine conjugated MAVGG had higher tumor uptake and tumor to normal tissue ratios, which suggested that the tumor uptake property of a peptide may be improved by introducing a nucleotide base. The high contrasted tumor images of 99mTc-MAVGG-adenine also suggested its potential utility as tumor imaging agent.
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ISSN:0236-5731
1588-2780
DOI:10.1007/s10967-007-0705-0