Systematic screening for digestive carriage of extended-spectrum β-lactamase-producing Enterobacterales (E-ESBL) at hospital readmission among patients with past history of E-ESBL colonization or infection

• Published in: The Journal of hospital infection Vol. 131; pp. 126 - 128
• Main Authors: Bouchand, C., Bourigault, C., Le Gallou, F., Corvec, S., Andréo, A., Lepelletier, D.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.01.2023
• Subjects: beta-Lactamases; Digestive carriage; E-ESBL; Enterobacteriaceae; Enterobacteriaceae Infections - diagnosis; Enterobacteriaceae Infections - epidemiology; Enterobacteriaceae Infections - microbiology; Gammaproteobacteria; Hospital readmission; Humans; Isolation measures; Patient Readmission; Retrospective Studies; E-ESBL; Digestive carriage; Isolation measures; Hospital readmission
• ISSN: 0195-6701; 1532-2939
• DOI: 10.1016/j.jhin.2022.10.004

Extended-spectrum β-lactamase-producing Enterobacterales (E-ESBL) are commensal multidrug-resistant (MDR) bacteria of the digestive tract whose prevalence has risen sharply worldwide and in Europe over the past two decades. To assess digestive carriage at hospital readmission of a large cohort of 2509 patients with E-ESBL carriage over a five-year survey; 833 (33%) patients were readmitted at least once. A retrospective, single-centre survey conducted at a tertiary care hospital in France. Among patients with several hospital readmissions (range: 2–13), the proportion of patients still E-ESBL-colonized at hospital readmission, detected by systematic screening for E-ESBL colonization, was >80% within an 18-month period after prior hospitalization with the first E-ESBL isolation. There is a need to reconsider the continuation of systematic screening for E-ESBL colonization because of a high rate of patients still colonized at hospital readmission over a long period of time.