Detection of the SARS-CoV-2 Nucleocaspid Protein (NP) Using Immunohistochemistry

While lymphocytopenia is a common characteristic of patients infected by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the mechanisms responsible for this depletion are unclear. With the tissue samples of the spleens and lymph nodes (LNs) from six cases, immunohistochemistr...

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Published inBio-protocol Vol. 10; no. 7
Main Authors Feng, Zeqing, Diao, Bo, Wang, Rongshuai, Wang, Gang, Wang, Chenhui, Tan, Yingjun, Liu, Liang, Wang, Changsong, Liu, Ying, Liu, Yueping, Yuan, Zilin, Ren, Liang, Wu, Yuzhang, Chen, Yongwen
Format Journal Article
LanguageEnglish
Published Bio-protocol LLC 01.04.2020
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Summary:While lymphocytopenia is a common characteristic of patients infected by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the mechanisms responsible for this depletion are unclear. With the tissue samples of the spleens and lymph nodes (LNs) from six cases, immunohistochemistry demonstrated ACE2 (angiotensin-converting enzyme 2), the potential receptor of SARS-CoV-2, expresses on tissue-resident CD169+ macrophages in spleens and LNs.
ISSN:2331-8325
2331-8325
DOI:10.21769/BioProtoc.5002