Correlations between hematological indicators and other known markers in acute coronary syndromes

Introduction: Recently, many hematologic markers have identified as prognostic and diagnostic indicators in different acute coronary syndrome (ACS) patients. In particular, neutrophil / lymphocyte ratio (NLR) and platelet / lymphocyte ratio (PLR) are recognized as markers in the diagnosis and progno...

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Published inKardiyovasküler tıp e dergisi Vol. 5; no. 4; pp. 67 - 74
Main Authors Ertürk, Mehmet, Turhan Caglar, Fatma N., Bıyık, İsmail
Format Journal Article
LanguageEnglish
Published Ismir Galenos Publishing House 15.12.2017
Subjects
Acute coronary syndromes
Angina pectoris
Atherosclerosis
Blood platelets
Blood tests
Cardiovascular disease
Confidence intervals
Enzymes
Heart attacks
Hematology
Inflammation
Inflammatory diseases
Lymphocytes
Mortality
Neutrophils
Statistical analysis
Thrombosis
Switzerland
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Summary:Introduction: Recently, many hematologic markers have identified as prognostic and diagnostic indicators in different acute coronary syndrome (ACS) patients. In particular, neutrophil / lymphocyte ratio (NLR) and platelet / lymphocyte ratio (PLR) are recognized as markers in the diagnosis and prognosis of ACS. In this study, our aim was to investigate the correlation between the diagnostic yield of PLR and NLR values and other markers such as troponin in all ACS patients. Material and methods: 319 patients admitted to our hospital with ACS and 283 control patients were included in the study. Leukocyte, neutrophil, platelet, lymphocyte counts, PLR, NLR and high sensitive troponin I (HsTnI) measurements were taken. Results: Leukocyte, neutrophil and platelet counts were significantly higher in the ACS group than the controls (p <0.001). Lymphocyte count was significantly lower in the ACS group than the controls (p <0.001). NLR and PLR were found to be significantly higher in the ACS group than the controls (4.0 ± 3.3 vs 2.1 ± 1.4 and 126.3 ± 68.9 vs 106.9 ± 49.4, p <0.001, respectively). NLR was showed significant correlation with HsTnI, PLR, angina time, presence of ST elevation and T wave negativity (p <0.05), and PLR revealed significant correlation with NLR, HsTnI, ST elevation and T wave negativity (p <0.05). Conclusion: Hematologic markers were found to be significantly higher in the ACS group than the controls. The difference also continued in subgroup analyzes. NLR and PLR correlated with many other ACS indicators.
ISSN:2147-1924
2147-1924
DOI:10.15511/ejcm.17.00467