Investigation of Levan-Derived Nanoparticles of Dolutegravir: A Promising Approach for the Delivery of Anti-HIV Drug as Milk Admixture

• Published in: Journal of pharmaceutical sciences Vol. 113; no. 8; pp. 2513 - 2523
• Main Authors: Lakshmi Sadhana, S., Priya Dharshini, K., Ramya Devi, D., Naryanan, Vedha Hari B., Veerapandian, Bhuvaneshwari, Luo, Rong-Hua, Yang, Jin-Xuan, Shanmugam, Saravanan Ramiah, Ponnusami, V., Brzezinski, Marek, Zheng, Yong-Tang
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2024
• Subjects: Biopolymer; Dolutegravir; Levan; Milk admixture; Nanoparticle; Spray dying; Spray dying; Milk admixture; Levan; Nanoparticle; Biopolymer; Dolutegravir

Nanoparticles composed of Levan and Dolutegravir (DTG) have been successfully synthesized using a spray drying procedure specifically designed for milk/food admixture applications. Levan, obtained from the microorganism Bacillus subtilis, was thoroughly characterized using MALDI-TOF and solid-state...