18F-FDG PET/CT Findings in a Rare Case of Paraneoplastic Vestibulocerebellar Syndrome Associated With Isolated Antiamphiphysin Antibodies

• Published in: Clinical nuclear medicine Vol. 47; no. 2; p. e125
• Main Authors: Komandla, Shivaram Rao, Vankadari, Kousik, Milap, Milap, V, Hemanth, Kandadai, Rukmini Mridula
• Format: Journal Article
• Language: English
• Published: United States 01.02.2022
• Subjects: Autoantibodies; Fluorodeoxyglucose F18; Humans; Nerve Tissue Proteins; Paraneoplastic Cerebellar Degeneration; Positron Emission Tomography Computed Tomography
• ISSN: 1536-0229
• DOI: 10.1097/RLU.0000000000003868

Paraneoplastic cerebellar degeneration (PCD) is an immune-mediated neurological disease characterized by adaptive immune response against onconeural antigens physiologically expressed in the cerebellum. It is characterized by presence of highly specific onconeural autoantibodies such as anti-Yo, anti-Hu, anti-Ri, and anti-Ma2 in the serum and cerebrospinal fluid as diagnostic biomarkers. Antiamphiphysin autoantibody-related paraneoplastic encephalitis is a less commonly seen autoimmune neurological disorder usually presenting as stiff person syndrome. We present an unusual case of isolated antiamphiphysin antibody-related PCD presenting as vestibulocerebellar syndrome with associated sensorineural hearing loss and sensory neuropathy. FDG PET helped in topographical localization of brain lesion along with early detection of extragonadal germ cell tumor in the retroperitoneum.