Role of the M1 receptor in regulating circadian rhythms

Cholinergic stimuli are potent regulators of the circadian clock in the hypothalamic suprachiasmatic nucleus (SCN). Using a brain slice model, we have found that the SCN clock is subject to muscarinic regulation, a sensitivity expressed only during the night of the clock's 24-h cycle. Pharmacol...

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Bibliographic Details
Published inLife sciences (1973) Vol. 68; no. 22-23; pp. 2467 - 2472
Main Authors Gillette, Martha U., Buchanan, Gordon F., Artinian, Liana, Hamilton, Susan E., Nathanson, Neil M., Liu, Chen
Format Journal Article
LanguageEnglish
Published Netherlands 27.04.2001
Subjects
Animals
Carbachol - pharmacology
Cholinergic Agonists - pharmacology
Circadian Rhythm - physiology
Cyclic GMP - analogs & derivatives
Cyclic GMP - pharmacology
In Vitro Techniques
Models, Biological
Muscarinic Antagonists - pharmacology
Neurons - drug effects
Neurons - physiology
Rats
Receptor, Muscarinic M1
Receptors, Muscarinic - metabolism
Signal Transduction
Suprachiasmatic Nucleus - drug effects
Suprachiasmatic Nucleus - physiology
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Summary:Cholinergic stimuli are potent regulators of the circadian clock in the hypothalamic suprachiasmatic nucleus (SCN). Using a brain slice model, we have found that the SCN clock is subject to muscarinic regulation, a sensitivity expressed only during the night of the clock's 24-h cycle. Pharmacological and signal transduction characteristics are compatible with a response mediated by an M1-like receptor. Molecular manipulation of muscarinic receptors will provide important insights as to the receptor subtype(s) regulating circadian rhythms.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:0024-3205
DOI:10.1016/S0024-3205(01)01040-2