Synthesis and biodistribution of 99mTc-peptides conjugated adenine as tumor imaging agents

Two peptide ligands conjugated adenine, [9-N-(tritylmercapto acetyl diglycyl aminoethyl) adenine, Tr-MAG2-Ade] and [9-N-(tritylmercapto acetyl triglycyl aminoethyl) adenine, Tr-MAG3-Ade], are synthesized and labeled with 99mTc by directly labeling method. The stability of 99mTc-MAG2- adenine and 99m...

Full description

Saved in:
Bibliographic Details
Published inJournal of radioanalytical and nuclear chemistry Vol. 273; no. 1; pp. 9 - 13
Main Authors Zhao, Y L, Zhang, C L, Qi, C M, Feng, S J, You, G R, Fu, Z L, Guo, F G, Wang, R F
Format Journal Article
LanguageEnglish
Published 01.07.2007
Online AccessGet full text

Cover

More Information
Summary:Two peptide ligands conjugated adenine, [9-N-(tritylmercapto acetyl diglycyl aminoethyl) adenine, Tr-MAG2-Ade] and [9-N-(tritylmercapto acetyl triglycyl aminoethyl) adenine, Tr-MAG3-Ade], are synthesized and labeled with 99mTc by directly labeling method. The stability of 99mTc-MAG2- adenine and 99mTc-MAG3-adenine in vitro is measured. The uptake radios of tumor to muscle at 3h post-injection are 5.70 and 4.92, respectively. The biodistribution and scintigraphic imaging studies show that the two complexes have high localization in tumor and high contrasted tumor images can be obtained, which suggest their potential utility as tumor imaging agents. But the high radioactivity of abdomen could prevent the tumor imaging in this area.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
SourceType-Scholarly Journals-2
ObjectType-Feature-2
ObjectType-Conference Paper-1
SourceType-Conference Papers & Proceedings-1
ObjectType-Article-3
ISSN:0236-5731
1588-2780
DOI:10.1007/s10967-007-0702-3