The value of volatile fatty acids, citrulline and malondialdehyde for diagnosis of suppurative cholangitis in obstructive jaundice and choosing of optimal surgical approach (with commentary)

• Published in: Hirurgija (Moskva) no. 10; p. 41
• Main Authors: Gagua, A K, Strel'nikov, A I, Val'kov, K S
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2016
• Subjects: Bacteria, Anaerobic - metabolism; Cholangitis - complications; Cholangitis - diagnosis; Cholangitis - microbiology; Cholangitis - physiopathology; Citrulline - analysis; Early Diagnosis; Fatty Acids, Volatile - analysis; Female; Humans; Jaundice, Obstructive - diagnosis; Jaundice, Obstructive - etiology; Jaundice, Obstructive - surgery; Male; Malondialdehyde - analysis; Middle Aged; Patient Selection; Reproducibility of Results; Suppuration - diagnosis; Surgical Procedures, Operative - methods
• ISSN: 0023-1207
• DOI: 10.17116/hirurgia20161041-47

To define the role of volatile fatty acids, citrulline and malondialdehyde for diagnosis of suppurative cholangitis in obstructive jaundice and to define optimal surgical approach. We studied the results of examination and treatment of 87 patients with different hepatopancreatobiliary pathology complicated by obstructive jaundice. It was determined blood concentration and range of volatile fatty acids which are metabolites of facultative anaerobic and obligate anaerobic bacterial pathogens. In 39 patients the defined levels of acetic, propionic, butyric and isovaleric acids contributed to accurate diagnosis of suppurative cholangitis. Statistically significant threshold concentrations of volatile fatty acids were revealed. These values facilitate detection of anaerobic microflora in suppurative cholangitis. Research of contents of volatile fatty acids, citrulline and malondialdehyde contributes to early diagnosis of suppurative cholangitis in patients with obstructive jaundice and further objectifies an algorithm of surgical tactics.