In Vivo High-Resolution Bioimaging of Bone Marrow and Fracture Diagnosis Using Lanthanide Nanoprobes with 1525 nm Emission

• Published in: Nano letters Vol. 22; no. 7; pp. 2691 - 2701
• Main Authors: Li, Youbin, Wen, Xingwang, Deng, Zhiming, Jiang, Mingyang, Zeng, Songjun
• Format: Journal Article
• Language: English
• Published: United States 13.04.2022
• Subjects: Bone Marrow - diagnostic imaging; Brain; Fractures, Bone; Humans; Lanthanoid Series Elements; Nanoparticles; Optical Imaging - methods; NIR-IIb emissive lanthanide nanoprobe; bone marrow imaging; bone fracture diagnosis; high-resolution bone imaging
• ISSN: 1530-6984; 1530-6992
• DOI: 10.1021/acs.nanolett.1c04531

Bones play vital roles in human health. Noninvasive visualization of the full extent of bones is highly demanded to evaluate many bone-related diseases. Herein, we report poly (acrylic acid) (PAA)-modified NaLuF :Yb/Er/Gd/Ce@NaYF nanoparticles (PAA-Er) with second near-infrared emission beyond 1500 nm (also referred as NIR-IIb) for high-resolution bone/bone marrow imaging and bone fracture diagnosis. The NIR-IIb optical-guided bone marrow imaging presents a high signal to noise ratio, which is superior to that for imaging in the NIR-II window (1000-1400 nm, NIR-IIa). Importantly, we also investigated the size-dependent accumulation of the nanoparticles and the possible accumulation mechanism of the designed PAA-Er nanoprobes in bone marrow. Due to the high affinity capability of the PAA-Er nanoprobes, a highly sensitive NIR-IIb optical-guided bone fracture diagnosis was successfully achieved. This novel technology paves the way to design lanthanide nanoprobes for NIR-IIb optical-guided high-resolution bone marrow imaging and bone-related disease diagnosis.