Isolated Central Nervous System Relapse of Non-Seminomatous Germ Cell Tumour of the Testis

Isolated central nervous system (CNS) relapse of non-seminomatous germ cell tumour (NSGCT) of the testis has been reported in only 12 patients previously. We report a patient with an isolated CNS relapse of NSGCT, following a prior systemic relapse. From a review of previous cases, isolated CNS rela...

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Bibliographic Details
Published inOncology Vol. 61; no. 3; pp. 184 - 188
Main Authors Cohn, Deborah A., Stuart-Harris, Robin
Format Journal Article
LanguageEnglish
Published Basel, Switzerland 01.01.2001
Subjects
Clinical Study
Central nervous system relapse
Isolated relapse
Non-seminoma
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Summary:Isolated central nervous system (CNS) relapse of non-seminomatous germ cell tumour (NSGCT) of the testis has been reported in only 12 patients previously. We report a patient with an isolated CNS relapse of NSGCT, following a prior systemic relapse. From a review of previous cases, isolated CNS relapse appears to be more common in patients with embryonal cell histology (alone or mixed with other elements) and occurred after a median of 8.5 months following initial presentation. Long-term survival appears possible using multi-modal treatment with whole-brain radiotherapy, surgery and/or chemotherapy. However, the optimal treatment of isolated CNS relapse remains undefined.
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ISSN:0030-2414
1423-0232
DOI:10.1159/000055372