Chemopreventive effects of garlic and mugwort mixture extract on Helicobacter pylori-associated mouse gastric carcinogenesis

• Published in: Korean journal of veterinary research Vol. 54; no. 3; pp. 171 - 177
• Main Authors: So Young Youm, Tae Wang Kim, Sang Kyung Shin, Heon Sang Jeong, Jong Koo Kang, Tae Myoung Kim, Kil Ho Kim, Byeong Woo Ahn
• Format: Journal Article
• Language: English
• Published: 대한수의학회 30.09.2014
• Subjects: 수의학; garlic; mouse; gastric cancer; Helicobacter pylori; artemisia
• ISSN: 2466-1384; 2466-1392
• DOI: 10.14405/kjvr.2014.54.3.171

Garlic and mugwort have long been used in traditional medicine to prevent various diseases. Several invitro studies have reported protective efficacies of garlic and mugwort in cases of gastric cancer. In the present study,we investigated the cancer preventive effects of garlic and mugwort mixture extract (GME) in a Helicobacter (H.)pylori-associated gastric carcinogenesis mouse model. To induce gastric cancer, C57BL/6 mice were treated with Nmethyl-N-nitrosourea and H. pylori. Various concentrations of GME (0, 100, 500, and 1,000 ppm) were then fed tothe mice for 38 weeks, after which the tumor tissues were examined for histopathology, mucin histochemistry andβ-catenin. The incidence of gastric tumors was significantly lower in the highest dose GME-treated mice (46.7%) thancontrol mice (85.7%) (p < 0.05). The multiplicity and size of tumors were also significantly reduced by GME feedingin a dose-dependent manner (p < 0.01). Furthermore, GME suppressed the H. pylori-associated chronic inflammationmeasured by histologic grading of H. pylori density, chronic gastritis, glandular atrophy and intestinal metaplasia innon-tumorous gastric mucosae. Our data suggest that GME suppresses gastric tumorigenesis via suppression of H. pylori-associated chronic inflammation. KCI Citation Count: 0