674a Prognostic value of steroid receptors after long term follow up of 2257 operable breast cancer patients
The prognostic value ofestradiol receptor (ER) and progesterone receptor (PR) was estimated by a multicentric study of 2257 operable breast cancer patients without any adjuvant treatment, followed up for a median of 8.5 years. The series included 33.3% stage I, 57.1% stage II, 5.7% stage IIIa and 2....
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Published in | European journal of cancer (1990) Vol. 31; p. S141 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Elsevier Ltd
01.11.1995
|
Online Access | Get full text |
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Summary: | The prognostic value ofestradiol receptor (ER) and progesterone receptor (PR) was estimated by a multicentric study of 2257 operable breast cancer patients without any adjuvant treatment, followed up for a median of 8.5 years. The series included 33.3% stage I, 57.1% stage II, 5.7% stage IIIa and 2.4% stage IIIb. At the endpoint of the study were observed 589/2257 (26.1%) metastases and 673/2257 (29.8%) deaths. Receptors were measured by radioligand assay. Of the tumours, 68.8%, were ER
+
and 54.0% PR
+
(≥
10
fmol/mg cytosol protein).
In univariate analysis, ER and PR status were of prognostic value (
P
<
0.001) for the disease-free interval (DFI), the metastases-free interval (MFI) and the overall survival (OS). The OS after a first metastase was also significantly different between ER
+
and ER− tumours (
p
<
0.001).
In multivariate analysis (Cox's proportional hazard model), only the ER status showed a significant difference (
P
<
0.01) between
+
and
−
groups for DFI, MFI and OS. By using Cox's non-proportional, timedependant models, we show that the predictive value of ER status is decreasing by approximately 20% per year, loosing its significance after 8 years of follow-up.
Overall, when compared to the TNM and histological grading, ER and PR status have a small prognostic value, their major interest remaining in the domain of therapeutic decisions. |
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ISSN: | 0959-8049 1879-0852 |
DOI: | 10.1016/0959-8049(95)95923-T |