Deracemisation of racemic 2-substituted indolines by monoamine oxidase from Pseudomonas monteilii ZMU-T01

[Display omitted] •A new function of monoamine oxidase (MAO-5) was found.•Bio-mediated oxidative resolution of racemic 2-substituted indolines was developed.•(R)-2-methyl-indoline and its derivates was obtained with high enantioselectivity by biocatalytic process. Monoamine oxidase strain (MAO-5) fr...

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Published inTetrahedron letters Vol. 113; p. 154249
Main Authors Qin, Lei, Deng, Guozhong, Du, Lei, Cui, Baodong, Wan, Nanwei, Chen, Yongzheng
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 21.12.2022
Subjects
2-Substituted indolines
Monoamine oxidase
Oxidative resolution
Pseudomonas monteilii
Oxidative resolution
Pseudomonas monteilii
Monoamine oxidase
2-Substituted indolines
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Summary:[Display omitted] •A new function of monoamine oxidase (MAO-5) was found.•Bio-mediated oxidative resolution of racemic 2-substituted indolines was developed.•(R)-2-methyl-indoline and its derivates was obtained with high enantioselectivity by biocatalytic process. Monoamine oxidase strain (MAO-5) from Pseudomonas monteilii ZMU-T01 mediated oxidative resolution of racemic 2-substituted indolines has been successfully described. A series of highly enantioselective 2-substituted indoline derivatives were obtained in up to 50 % conversion and >99 % ee.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2022.154249