Deracemisation of racemic 2-substituted indolines by monoamine oxidase from Pseudomonas monteilii ZMU-T01
[Display omitted] •A new function of monoamine oxidase (MAO-5) was found.•Bio-mediated oxidative resolution of racemic 2-substituted indolines was developed.•(R)-2-methyl-indoline and its derivates was obtained with high enantioselectivity by biocatalytic process. Monoamine oxidase strain (MAO-5) fr...
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Published in | Tetrahedron letters Vol. 113; p. 154249 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Elsevier Ltd
21.12.2022
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Subjects | |
Online Access | Get full text |
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Summary: | [Display omitted]
•A new function of monoamine oxidase (MAO-5) was found.•Bio-mediated oxidative resolution of racemic 2-substituted indolines was developed.•(R)-2-methyl-indoline and its derivates was obtained with high enantioselectivity by biocatalytic process.
Monoamine oxidase strain (MAO-5) from Pseudomonas monteilii ZMU-T01 mediated oxidative resolution of racemic 2-substituted indolines has been successfully described. A series of highly enantioselective 2-substituted indoline derivatives were obtained in up to 50 % conversion and >99 % ee. |
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ISSN: | 0040-4039 1873-3581 |
DOI: | 10.1016/j.tetlet.2022.154249 |