Preclinical evaluation of 99mtechnetium-labeled DD-3B6/22 FAB' for thrombus detection

Injection of 99mTc-labeled Fab' fragments of the anti-fibrin antibody DD3B6/22, in the baboon, resulted in clear visualisation of both fresh and aged autologous thrombi by gamma scintigraphy. Whole body scintigraphy, pharmacokinetics and urine analysis showed rapid renal excretion of the conjug...

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Published inThrombosis research Vol. 64; no. 6; pp. 691 - 701
Main Authors Walker, K.Z., Boniface, G.R., Phippard, A.F., Harewood, W., Bautovich, G.J., Bundesen, P.G.
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.12.1991
Subjects
clots
fibrin
monoclonal antibodies
scintigraphy
thrombosis
clots
thrombosis
fibrin
scintigraphy
monoclonal antibodies
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Summary:Injection of 99mTc-labeled Fab' fragments of the anti-fibrin antibody DD3B6/22, in the baboon, resulted in clear visualisation of both fresh and aged autologous thrombi by gamma scintigraphy. Whole body scintigraphy, pharmacokinetics and urine analysis showed rapid renal excretion of the conjugate with little accumulation of label in other organs. 99mTc-DD-3B6/22 Fab' appears a suitable candidate for further investigation as a radioimaging agent for thrombi in humans.
ISSN:0049-3848
1879-2472
DOI:10.1016/0049-3848(91)90069-9