Synthesis of new β2,2-amino acids with carbohydrate side chains: impact on the synthesis of peptides

• Published in: Carbohydrate research Vol. 388; pp. 8 - 18
• Main Authors: Sharma, Gangavaram V.M., Rajender, Karnekanti, Sridhar, Gattu, Reddy, Post Sai, Kanakaraju, Marumudi
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 31.03.2014
• Subjects: Carbohydrate side chain; Geminally disubstituted; β2,2-Amino acids; β2,2-Peptides; Carbohydrate side chain; β2,2-Amino acids; β2,2-Peptides; Geminally disubstituted
• ISSN: 0008-6215; 1873-426X
• DOI: 10.1016/j.carres.2014.01.026

•Synthesis of new geminally disubstituted C-linked carbo-β2,2-amino acids (β2,2-Caas).•Synthesis of new class of peptides.•Impact of carbohydrate side chains on the synthesis of peptides.•The impact on the absence of C-3 –OMe on the β2,2-peptides. The study describes the synthesis of new geminally disubstituted C-linked carbo-β2,2-amino acids (β2,2-Caas) with different carbohydrate side chains, and their use in the synthesis of β2,2-peptides. The study infers that the side chain has an influence on the synthesis of peptides and their conformational behaviour.