Neural correlates of category learning in monkey inferior temporal cortex

• Published in: The Journal of neuroscience p. e0312242024
• Main Authors: Pearl, Jonah E, Matsumoto, Narihisa, Hayashi, Kazuko, Matsuda, Keiji, Miura, Kenichiro, Nagai, Yuji, Miyakawa, Naohisa, Minanimoto, Takafumi, Saunders, Richard C, Sugase-Miyamoto, Yasuko, Richmond, Barry J, Eldridge, Mark A G
• Format: Journal Article
• Language: English
• Published: United States 18.10.2024
• ISSN: 0270-6474; 1529-2401; 1529-2401
• DOI: 10.1523/JNEUROSCI.0312-24.2024

Area TE is required for normal learning of visual categories based on perceptual similarity. To evaluate whether category learning changes neural activity in area TE, we trained two monkeys (both male) implanted with multi-electrode arrays to categorize natural images of cats and dogs. Neural activity during a passive viewing task was compared pre- and post-training. After the category training, the accuracy of abstract category decoding improved. Single units became more category-selective, the proportion of single units with category-selectivity increased, and units sustained their category-specific responses for longer. Visual category learning thus appears to enhance category separability in area TE by driving changes in the stimulus selectivity of individual neurons and by recruiting more units to the active network. Neurons in Area TE are known to respond selectively to a small number of visual stimuli. Here we demonstrate that the neural activity in area TE is modulated by category learning of natural images (cats and dogs), thus demonstrating that this region is capable of undergoing rapid plastic changes in adult primates.