Haemoglobin F melbourne Gγ16 Gly å Arg and haemoglobin F carlton [formula omitted]. Further evidence for varied activity of γ-chain genes

• Published in: Biochimica et biophysica acta. Protein structure Vol. 490; no. 2; pp. 452 - 455
• Main Authors: Brennan, S.O., Smith, Merran B., Carrell, R.W.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.02.1977
• ISSN: 0005-2795; 1879-2952
• DOI: 10.1016/0005-2795(77)90020-4

Two new foetal haemoglobin variants are reported: haemoglobin F Melbourne G γ16 Gly a ̊ Arg forming 29% of the total haemoglobin F in cord blood and haemoglobin F Carlton G γ121 Glu a ̊ Lys forming 26% of the haemoglobin F in cord blood. The amino acid substitution at residue 121 in haemoglobin F Carlton is identical to that of haemoglobin F Hull, however, the latter originates from the A γ gene while haemoglobin F Carlton arises from the G γ gene.