The state of the intestinal microbiota as one of the pathogenetic factors in the development of metabolic disorders and a therapeutic target in children with obesity (literature review, own research)

• Published in: Suchasna pediatrii︠a︡. Ukraïna no. 5(125); pp. 93 - 102
• Main Authors: Kryuchko, T., Poda, O., Nesina, I., Kolenko, I., Cherevko, I.
• Format: Journal Article
• Language: English; Ukrainian
• Published: 30.09.2022
• ISSN: 2663-7553; 2706-6134
• DOI: 10.15574/SP.2022.125.93

The high prevalence of obesity among children and adolescents at the current stage is an important medical and social problem in pediatric practice. The presence of obesity in children is a significant risk factor for the development of metabolic disorders in the body. Pathogenetic mechanisms of the development of metabolic disorders in obese people remain to be fully understood, but the presence of a chronic inflammatory process in the body is considered to be one of the key factors in their formation. For today, many scientists are studying the state of the intestinal microbiota as one of the likely triggers of chronic inflammation and the development of metabolic changes in obese people. Purpose - to summarize the literature data and the results of our own research on the effectiveness of the therapeutic effect of probiotic cultures on the main metabolic indicators in children with obesity. Results and conclusions. At the current stage, scientific researches on the study the role of intestinal microbiota both as a marker of metabolic changes in the body of obese people and as a potential therapeutic target are continuing. According to systematic reviews, the level of pro-inflammatory cytokines in the body of obese people is significantly increased and pronounced dysbiotic disturbances are noted. Addition of probiotic cultures to therapy has been reported by various researchers to improve basic metabolic parameters and reduce inflammatory markers in obese people. As a result of our own research, improvements in carbohydrate and lipid metabolism indicators, the structural and functional state of the liver, and the general condition of obese children who took a synbiotic drug in complex treatment were revealed. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of all participating institutions. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors.