Microwave mediated hydrogen deuterium exchange: a rapid synthesis of 2H-substituted benzimidazole
Aromatic deuterium compounds were prepared from the unlabeled parent compounds under microwave irradiation. This novel methodology was applied to the deuterium substituted benzimidazole derivative. Deuterium aromatic substituted compounds were prepared by microwave irradiation of the parent unlabele...
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| Published in | Tetrahedron letters Vol. 46; no. 31; pp. 5195 - 5197 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
Elsevier Ltd
01.08.2005
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Aromatic deuterium compounds were prepared from the unlabeled parent compounds under microwave irradiation. This novel methodology was applied to the deuterium substituted benzimidazole derivative.
Deuterium aromatic substituted compounds were prepared by microwave irradiation of the parent unlabeled compounds in the presence of deuterium oxide and deuterium chloride. The percentage of deuterium incorporation was investigated under various reaction conditions. A rapid synthesis of
2H-substituted benzimidazole under microwave irradiation is described. |
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| AbstractList | Aromatic deuterium compounds were prepared from the unlabeled parent compounds under microwave irradiation. This novel methodology was applied to the deuterium substituted benzimidazole derivative.
Deuterium aromatic substituted compounds were prepared by microwave irradiation of the parent unlabeled compounds in the presence of deuterium oxide and deuterium chloride. The percentage of deuterium incorporation was investigated under various reaction conditions. A rapid synthesis of
2H-substituted benzimidazole under microwave irradiation is described. |
| Author | Surber, Bruce W. Vaidyanathan, Srirajan |
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| Cites_doi | 10.1002/anie.200400655 10.1124/dmd.32.6.647 10.1002/jlcr.2580340308 10.1039/b005724j 10.1016/j.tetasy.2004.11.040 10.1002/jlcr.2580150176 10.1016/j.tetlet.2003.12.002 10.1016/j.tetlet.2005.01.025 10.1351/pac200173010193 10.1016/S0040-4020(01)01216-9 10.1021/jm030505a |
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| References | bib9 Anto, Getvoldsen, Harding, Jones, Lu, Russell, Cioffi, Bell, Le, Koves (bib5) 2000; 16 bib7 Freed, Murphy (bib2) 1978 Varma, Varma (bib4) 2001; 73 bib8 Walsky, Opbach (bib1) 2004; 32 Kim, Varma, Varma, Kappe, Bose, Ganguly, Manhas, Vaidyanathan, Bhattacharjee, Rumthao, Sharma (bib3) 2005; 46 bib6 Cowart, Latshaw, Bhatia, Daanen, Rohde, Nelson, Patel, Kolasa, Nakane, Uchic, Miller, Terranova, Chang, Donnelly-Roberts, Namovic, Hollingsworth, Martino, Lynch, Sullivan, Hsieh, Moreland, Brioni, Stewart (bib10) 2004; 47 Varma (10.1016/j.tetlet.2005.05.110_bib4_1) 2001; 73 Cioffi (10.1016/j.tetlet.2005.05.110_bib5_2) 2005; 16 Walsky (10.1016/j.tetlet.2005.05.110_bib1) 2004; 32 Anto (10.1016/j.tetlet.2005.05.110_bib5_1) 2000 Kim (10.1016/j.tetlet.2005.05.110_bib3_1) 2005; 46 Cowart (10.1016/j.tetlet.2005.05.110_bib10) 2004; 47 Bose (10.1016/j.tetlet.2005.05.110_bib3_4) 2004; 45 Koves (10.1016/j.tetlet.2005.05.110_bib5_3) 1994; 34 Kappe (10.1016/j.tetlet.2005.05.110_bib3_3) 2004; 43 Freed (10.1016/j.tetlet.2005.05.110_bib2) 1978 Varma (10.1016/j.tetlet.2005.05.110_bib3_2) 2002 Varma (10.1016/j.tetlet.2005.05.110_bib4_2) 2002; 58 |
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| Title | Microwave mediated hydrogen deuterium exchange: a rapid synthesis of 2H-substituted benzimidazole |
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