Microwave mediated hydrogen deuterium exchange: a rapid synthesis of 2H-substituted benzimidazole

Aromatic deuterium compounds were prepared from the unlabeled parent compounds under microwave irradiation. This novel methodology was applied to the deuterium substituted benzimidazole derivative. Deuterium aromatic substituted compounds were prepared by microwave irradiation of the parent unlabele...

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Bibliographic Details
Published inTetrahedron letters Vol. 46; no. 31; pp. 5195 - 5197
Main Authors Vaidyanathan, Srirajan, Surber, Bruce W.
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.08.2005
Subjects
Deuterium
Microwave
Deuterium
Microwave
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Summary:Aromatic deuterium compounds were prepared from the unlabeled parent compounds under microwave irradiation. This novel methodology was applied to the deuterium substituted benzimidazole derivative. Deuterium aromatic substituted compounds were prepared by microwave irradiation of the parent unlabeled compounds in the presence of deuterium oxide and deuterium chloride. The percentage of deuterium incorporation was investigated under various reaction conditions. A rapid synthesis of 2H-substituted benzimidazole under microwave irradiation is described.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2005.05.110