Effect of radix Salviae miltiorrhizae on the gene expression of nitric oxide synthase in ischemic rat brains

The effect of Radix Salviae Miltiorrhizae (RSM) on the gene expression of nitric oxide synthase (NOS) in rat brains during ischemia was studied with in situ hybridization and the results were analyzed with IBAS 2000 Image Analysis System. It was found that NOS gene expression of cerebral cortex and...

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Bibliographic Details
Published inJournal of traditional Chinese medicine Vol. 18; no. 2; p. 128
Main Authors Wu, W, Kuang, P, Li, Z
Format Journal Article
LanguageEnglish
Published China 01.06.1998
Subjects
Animals
Brain - enzymology
Brain Ischemia - enzymology
Brain Ischemia - genetics
Drugs, Chinese Herbal - pharmacology
Gene Expression
Male
Nitric Oxide Synthase - biosynthesis
Nitric Oxide Synthase - genetics
Nitric Oxide Synthase Type I
Plant Extracts
Random Allocation
Rats
Rats, Sprague-Dawley
RNA, Messenger - biosynthesis
Salvia miltiorrhiza
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ISSN0255-2922

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Summary:The effect of Radix Salviae Miltiorrhizae (RSM) on the gene expression of nitric oxide synthase (NOS) in rat brains during ischemia was studied with in situ hybridization and the results were analyzed with IBAS 2000 Image Analysis System. It was found that NOS gene expression of cerebral cortex and caudate-putamen was markedly increased in 24 hours in ischemia group (P < 0.01). In RSM-treated rats, although the NOS gene expression of ischemic side was also increased as compared with contralateral cortex and caudate-putamen, it was significantly lower in RSM-treated rats than those of the controls (P < 0.05, P < 0.01). The present study indicates that RSM can partly inhibit NOS gene expression of cerebral cortex and caudate-putamen during ischemia. This may be one of the protective mechanisms of RSM on cerebral ischemia.
ISSN:0255-2922