Diagnosis and treatment of insulinoma: report of 105 cases

• Published in: Hepatobiliary & pancreatic diseases international Vol. 1; no. 1; pp. 137 - 139
• Main Authors: Feng, Liu-Shun, Ma, Xiu-Xian, Tang, Zhe, Zhao, Yong-Fu, Ye, Xue-Xiang, Xu, Pei-Qin
• Format: Journal Article
• Language: English
• Published: Singapore 01.02.2002
• Subjects: Adolescent; Adult; Aged; blood; Blood Glucose; cell; fasting; Female; glucose; Humans; insulinoma; Insulinoma - diagnostic imaging; Insulinoma - surgery; localization; Male; Middle Aged; Pancreatic Neoplasms - diagnostic imaging; Pancreatic Neoplasms - surgery; Postoperative Complications; Retrospective Studies; Treatment Outcome; tumor; Ultrasonography
• ISSN: 1499-3872

<正> Objective: To study the methods for diagnosis andtreatment of insulinoma.Methods: Clinical data from 105 patients with insuli-noma who had been admitted to our hospital from Ju-ly 1966 to December 1999 were retrospectively re-viewed.Results: Fasting blood glucose values were less than2.75 mmol/L in all the patients. Fasting serum insulinvalues in 60 patients were higher than 25 mU/L, av-erage 65 mU/L. Before operation, carcinoma was de-tected in 2 of 45 patients by ultrasound scan, and in10 of 35 by CT. Enucleation of insulinoma was per-formed in 60 patients. Operations included insulinomaresection (35 patients), distal resection of the pancreas(8), and biopsy (2).Conclusion: Whipple’s triad and the index of insulinrelease>0.3 are the major variables for diagno-sis Intraoperative exploration and ultrasound scan are themethods for the localization of insulinoma Enucleation ofbenign insulinoma is preferred, but proximal or distal re-sections of the pancreas are required only for large, deep ormultiple tumors