ET-1 gene expression of rat brain during ischemia and reperfusion and the protective effect of radix Salviae miltiorrhizae

• Published in: Journal of traditional Chinese medicine Vol. 17; no. 1; p. 59
• Main Authors: Wu, W, Kuang, P, Li, Z
• Format: Journal Article
• Language: English
• Published: China 01.03.1997
• Subjects: Animals; Brain - metabolism; Brain Ischemia - genetics; Brain Ischemia - metabolism; Brain Ischemia - prevention & control; Drugs, Chinese Herbal - pharmacology; Drugs, Chinese Herbal - therapeutic use; Endothelin-1 - biosynthesis; Endothelin-1 - drug effects; Endothelin-1 - genetics; In Situ Hybridization; Male; Plant Extracts; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury - genetics; Reperfusion Injury - metabolism; Reperfusion Injury - prevention & control; Salvia miltiorrhiza
• ISSN: 0255-2922

Endothelin-1 (ET-1) gene expression of rat brain during ischemia and reperfusion as well as the effect of Radix Salviae Miltiorrhizae (RSM) were studied with in situ hybridization. It was found that ET-1 gene expression of cerebral cortex and caudate-putamen was markedly increased both in 24 hours of ischemia and 24 hours of reperfusion groups (P < 0.01, P < 0.05). In RSM-treated rats, although the ET-1 gene expressions of ischemia and reperfusion sides were also increased as compared with contralateral cortex and caudate-putamen, they were significantly lower in RSM-treated rats than those of controls (P < 0.05, P < 0.01 respectively). The present study indicated that RSM can partly inhibit ET-1 gene expression of cerebral cortex and caudate-putamen during ischemia and reperfusion. This may be one of the protective mechanisms of RSM on cerebral ischemia and reperfusion.