The development of crystallization and X-ray crystallography method of long stem DNA

We clarified stabilization mechanism of left-handed Z-DNA by X-ray crystal structure analysis. I was able to achieve it by burying big minor groove of Z-DNA because metal ion and polyamine connected it to minor groove of Z-DNA. On that occasion I understood that an electric charge and length of poly...

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Published inNucleic Acids Symposium Series Vol. 49; no. 1; pp. 67 - 68
Main Authors Ohishi, Hirofumi, Tukamoto, Koji, Odoko, Mamiko, Grzeskowiak, Kazimierz, Maezaki, Naoyoshi, Okabe, Nobuo, Tanaka, Tetsuaki, Ishida, Toshimasa
Format Journal Article
LanguageEnglish
Published Oxford University Press 01.09.2005
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Summary:We clarified stabilization mechanism of left-handed Z-DNA by X-ray crystal structure analysis. I was able to achieve it by burying big minor groove of Z-DNA because metal ion and polyamine connected it to minor groove of Z-DNA. On that occasion I understood that an electric charge and length of polyamine gave big influence to a combination brain very much. I succeeded in crystallization of Z-DNA of a long chain, X-ray crystal structure analysis by examining these combination ability.
ISSN:0261-3166
1746-8272
DOI:10.1093/nass/49.1.67