Microarray-Based Screening of Putative HSP90 Inhibitors Predicted and Isolated from Microorganisms

Protein microarrays are useful tools for detecting the presence of a target where different prey and bait combinations exist. Here we describe the extended application for a functional target-oriented screening assay with full length Heat shock proteins (HSPs ) for the identification of novel compou...

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Bibliographic Details
Published inMethods in molecular biology (Clifton, N.J.) Vol. 2489; p. 435
Main Authors Kishore, Anusha, Fetter, Artem, Zeilinger, Carsten
Format Journal Article
LanguageEnglish
Published United States 2022
Subjects
Heat shock proteins
Protein microarray
Anti HSP90 inhibitor
Natural products
ATP-Cy5
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Summary:Protein microarrays are useful tools for detecting the presence of a target where different prey and bait combinations exist. Here we describe the extended application for a functional target-oriented screening assay with full length Heat shock proteins (HSPs ) for the identification of novel compounds.
ISSN:1940-6029
DOI:10.1007/978-1-0716-2273-5_22