Age related molecular-genetic preconditions for dental caries in pregnant women

The aim of the study was to evaluate the allelic polymorphisms kallikrein-4 (KLK-4) gene at the mutant points: G2664153A and G2142A in pregnant women under and over 30 of age. In pregnant women with KLK-4 gene polymorphisms A/A and G/A genotypes the rate of tooth decay growth increases in spite of a...

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Published inStomatologija (Moskva) Vol. 97; no. 2; p. 27
Main Authors Gorbunova, I L, Kravchenko, E N, Krivchik, G V, Shestovskikh, O L, Lukashevich, I K, Strometskaya, N N, Abramyan, I R
Format Journal Article
LanguageRussian
Published Russia (Federation) 2018
Subjects
Calcium - metabolism
Dental Caries - genetics
Female
Humans
Hydrogen-Ion Concentration
Kallikreins - genetics
Phosphorus - metabolism
Polymorphism, Genetic
Pregnancy
Pregnancy Complications - genetics
the indicators of oral fluid and oral fluid deposition
intensity of tooth decay growth
pregnant women
kallikrein-4 gene
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Summary:The aim of the study was to evaluate the allelic polymorphisms kallikrein-4 (KLK-4) gene at the mutant points: G2664153A and G2142A in pregnant women under and over 30 of age. In pregnant women with KLK-4 gene polymorphisms A/A and G/A genotypes the rate of tooth decay growth increases in spite of applying the ternary calcium-phosphate-fluoride-containing gel. This genotype is also associates with unfavorable alteration of such oral fluid indicators as pH, concentrations of inorganic phosphorus, the active concentrations of calcium and potassium, as well as the ratio of total calcium and phosphorus concentrations, the active concentrations of electrolytes, and demineralizing activity of oral fluid.
ISSN:0039-1735
DOI:10.17116/stomat201897227-31