Effect of radix Salviae miltiorrhizae on nitric oxide in cerebral ischemic-reperfusion injury

It has been postulated that nitric oxide (NO) is produced in significant amount on reperfusion of ischemic brain and could cause brain edema and cell death. This study was undertaken in an attempt to determine whether Radix Salviae Miltiorrhizae (RSM) could reduce cerebral NO contents in 4-vessel oc...

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Bibliographic Details
Published inJournal of traditional Chinese medicine Vol. 16; no. 3; p. 224
Main Authors Kuang, P, Tao, Y, Tian, Y
Format Journal Article
LanguageEnglish
Published China 01.09.1996
Subjects
Animals
Brain - metabolism
Brain Ischemia - metabolism
Drugs, Chinese Herbal - pharmacology
Male
Nitric Oxide - metabolism
Plant Extracts
Rats
Rats, Wistar
Reperfusion Injury - metabolism
Salvia miltiorrhiza
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Summary:It has been postulated that nitric oxide (NO) is produced in significant amount on reperfusion of ischemic brain and could cause brain edema and cell death. This study was undertaken in an attempt to determine whether Radix Salviae Miltiorrhizae (RSM) could reduce cerebral NO contents in 4-vessel occlusion rat model after 30 min of global ischemia and 15 min of reperfusion. There was a significant increase in cerebral NO level in untreated animals as compared with sham-operated ones. By pretreatment with RSM the cerebral NO concentration was reduced to normal level. The possibilities of neuroprotective role of RSM in cerebral ischemic-reperfusion injury were discussed.
ISSN:0255-2922