Chronic Diarrhea and Neutropenia Not Associated with Pancreatic Insufficiency: A Non-Shwachman-Diamond Entity

Six children with chronic diarrhea and neutropenia, initially referred for evaluation of Shwachman-Diamond syndrome, were found to have no evidence of pancreatic insufficiency. All presented in the spring with a prodromal respiratory illness. Hematologic evaluation was normal except for iron deficie...

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Bibliographic Details
Published inJournal of pediatric gastroenterology and nutrition Vol. 2; no. 3; pp. 559 - 562
Main Authors Marino, Lucyndia R, Dahms, Beverly B, Halpin, Thomas C
Format Journal Article
LanguageEnglish
Published United States Lippincott-Raven Publishers 01.08.1983
Subjects
Agranulocytosis - diagnosis
Child, Preschool
Diagnosis, Differential
Diarrhea - diagnosis
Exocrine Pancreatic Insufficiency
Female
Follow-Up Studies
Growth Disorders - diagnosis
Humans
Infant
Male
Neutropenia - diagnosis
Prognosis
Syndrome
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Summary:Six children with chronic diarrhea and neutropenia, initially referred for evaluation of Shwachman-Diamond syndrome, were found to have no evidence of pancreatic insufficiency. All presented in the spring with a prodromal respiratory illness. Hematologic evaluation was normal except for iron deficiency anemia and neutropenia. Small intestinal biopsies of all children showed inflammation, consistent with chronic enteritis. The children were followed until growth returned to previous percentiles. Diarrhea and neutropenia resolved by 6-month follow-up, and there was no recurrence of the neutropenia at 1 year.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0277-2116
1536-4801
DOI:10.1002/j.1536-4801.1983.tb08543.x