THE EFFECT OF TOPICAL APPLICATION WITH OZOILE® AS A NOVEL METHOD IN THE COMPLEX TREATMENT OF SOFT TISSUE INFECTIONS AND CHRONIC WOUNDS

The treatment of severe and deep soft tissue infections, especially those combined with fascial necrosis is complex and involves a multidisciplinary team. The aim is to research the effect of topical application of Ozoile®, stable ozonides from organic extra-virgin olive oil +OILin the complex treat...

Full description

Saved in:
Bibliographic Details
Published inTrakia journal of sciences Vol. 21; no. 3; pp. 237 - 246
Main Author Marinova, P.
Format Journal Article
LanguageEnglish
Published Trakia University 01.09.2023
Subjects
algorithm
ozoile
soft tissue infections
topical ozone therapy
Online AccessGet full text

Cover

More Information
Summary:The treatment of severe and deep soft tissue infections, especially those combined with fascial necrosis is complex and involves a multidisciplinary team. The aim is to research the effect of topical application of Ozoile®, stable ozonides from organic extra-virgin olive oil +OILin the complex treatment of soft tissue infections and chronic wounds and to optimize the algorithm of these applications. Results: We applied LOT to a total of 84 patients (22.1%) of all 380 patients with soft tissue infections treated for the period March 2022-March 2023 at the First surgical clinic of Medical University – Pleven, Bulgaria. At Department “Surgical diseases” there were 49 (58,3%) patients with the superficial inflammatory process, 6 (7,1%) with chronic wounds, and 27 (34,6%) with deep soft tissue infection and necrotizing fasciitis who received topical applications of Ozoile®, stable ozonides from organic extra-virgin olive oil +OIL®OT. We compared the results with a group of 296 patients treated with conventional methods and routinely used antiseptics – hydroperoxide, povidone-iodine, and chlorhexidine gluconate. Statistically significant results in the Ozoile® group were: wound size reduction by 25% on the 5th day of treatment (p<0.04), reduction by 50% of baseline C-reactive protein levels on day 5th of treatment (p < 0.05), the local status of the wound on the 30th day after discharge - in the Ozoile® group we did not observe any complaints of redness, itching or other local discomforts (p< 0.05). We optimized an algorithm for the application of ozone therapy with OzoilE®
ISSN:1312-1723
1313-3551
DOI:10.15547/tjs.2023.03.005