Association between serum chemerin level and severity of coronary artery disease in Egyptian patients with type 2 diabetes

• Published in: Journal of diabetology Vol. 7; no. 2; p. 4
• Main Authors: Lachine, N, ElSewy, FZ, Megallaa, MH, Sadaka, M, Khalil, G, Rohoma, K, Amin, NG
• Format: Journal Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2016
• Subjects: Chemerin; Coronary artery disease (CAD); High sensitivity C reactive protein (hs-CRP); HOMA-IR; type 2 diabetes
• ISSN: 2078-7685; 2078-7685
• DOI: 10.4103/2078-7685.198442

The objective of this study was to assess the relationship between serum chemerin level and the severity of coronary artery disease (CAD) in Egyptian patients with type 2 diabetes T2DM. The study included 160 subjects; divided into 4 equal groups; T2DM patients having CAD, CAD patients without diabetes, T2DM patients without CAD and a healthy control group. Serum chemerin level, and hs-CRP were measured and the severity of CAD was assessed using SYNTAX score. Serum chemerin was significantly higher in patients with CAD (p<0.001), with no difference however between diabetic and non-diabetic subjects (p= 0.16). Our results showed a significant positive correlation between serum chemerin and waist circumference (p=0.024) as well as waist to hip ratio (p=0.044). A significant association has been observed between the severity of CAD and each of serum chemerin (p <0.001) and hs-CRP (p =0.04). We report here a positive correlation between serum chemerin level and cardio-metabolic disease, with a significant association between serum chemerin concentration and severity of CAD in Egyptian patients with T2DM.