Development of Memantine Orodispersible Tablets and their In Vitro Description and Biopharmaceutical Performance

• Published in: International journal of pharmacokinetics Vol. 3; no. 1; pp. 13 - 21
• Main Authors: Peñaloza-Becerra, Carlos Adrián, Marcelín-Jimenez, Gabriel, López-González, Mariel Vanessa, Ortega-Escamilla, Ernesto, Vásquez-Vásquez, Juan Ernesto, Ángeles-Moreno, Alionka P, García-González, Alberto, Batista-Dieguez, Dany, Rodarte-Valle, Estefanía
• Format: Journal Article
• Language: English
• Published: London Newlands Press 01.02.2018
• Subjects: Alzheimer's disease; Bioavailability; Cell adhesion & migration; Chromatography; Dementia; Drug dosages; Geriatrics; Health care; Mass spectrometry; Older people; Pharmaceuticals; Population; Potassium; Public health; Scientific imaging; United States > US; Mexico
• ISSN: 2053-0846; 2053-0846
• DOI: 10.4155/ipk-2018-0001

Aim: New approaches are required to improve compliance in older patients with problems in swallowing traditional formulations. A novel memantine orodispersible tablet (ODT) was formulated, and its bioavailability and taste acceptability were evaluated. Materials & methods:In vitro characterization of ODT comprised dispersion in simulated saliva prior to dissolution assay in a limited volume of biorelevant media. A single oral dose of 20-mg memantine ODT exhibits similar bioavailability to that of an immediate release 20-mg tablet in a healthy population under fasting conditions. Results: 90% confidence interval for Cmax was of 96.78–106.52% and 98.27–104.78% for AUC0–72. An applied palatability survey showed exceptional acceptance of the formulation. Conclusion: Memantine microspheres prepared by a solid-dispersion technique results in ODT with adequate biopharmaceutical performance.