Comparison of vitreous/retinal pigment epithelium relative intensity in proliferative vitreoretinopathy and uveitis   [version 1; peer review: 2 approved with reservations]

• Published in: F1000 research Vol. 12; p. 807
• Main Authors: Djatikusumo, Ari, Victor, Andi Arus, Harahap, Alida Roswita, Wibowo, Heri, La Distia Nora, Rina, Setiabudy, Rianto, Sovani, Iwan, Edwar, Lukman, Permadi, Annisa Citra, Ardhia, Seruni Hanna
• Format: Journal Article
• Language: English
• Published: 2023
• Subjects: Proliferative Vitreoretinopathy; Vitreous/Retinal Pigment Epithelium-Relative Intensity; Uveitis
• ISSN: 2046-1402; 2046-1402
• DOI: 10.12688/f1000research.133812.1

Background: Quantitative measurements of vitreous inflammation using vitreous/retinal pigment epithelium-relative intensity (VIT/RPE-Relative Intensity) have been described recently. In proliferative vitreoretinopathy (PVR), inflammation plays a central role in the pathogenesis, inducing retinal fibrosis and contraction. However, no attempts have yet to be made to analyze the severity of inflammation in PVR progression. Methods: A cross-sectional study was conducted by reviewing OCT image sets obtained from patients divided into four groups: (1) proliferative vitreoretinopathy, (2) intermediate and posterior uveitis, (3) panuveitis, (4) normal healthy eyes in Cipto Mangunkusumo Kirana Eye Hospital between April 2021 - December 2021. OCT images were then analyzed in the ImageJ software for VIT/RPE-relative intensity. Results: A total of 19 PVR eyes, 12 intermediate-posterior uveitis eyes, 16 panuveitis eyes, and 28 normal healthy eyes were recruited for this study.  The VIT/RPE-Relative Intensity was significantly higher in PVR eyes (0.415±0.178) than in intermediate-posterior uveitis (0.236±0.043, p=0.002) and panuveitis eyes (0.30±0.07, p=0.023). Compared to the normal eyes, PVR and both uveitis groups have significantly higher VIT/RPE relative intensity (p = <0.001 in each group).  Conclusions: VIT/RPE-relative intensity may offer quantitative measurements of vitreous inflammation in the role of the pathogenesis of PVR. Comparison with cellular inflammation in the vitreous is required to validate this finding.