A molecular insight in the prevalence of odontogenic tumor

Odontogenic tumors (OT) encompass a diverse collection of lesions that ranges from hamartomas to benign and malignant neoplastic lesions of erratic aggressiveness. The progress and development of OT are influenced by variation of many kinds of genes and molecules. Genetic instability is a hallmark o...

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Bibliographic Details
Published inJournal of Advanced Clinical and Research Insights Vol. 3; no. 6; pp. 209 - 211
Main Authors Bhattacharjee, Kalpajyoti, Girish, H. C., Murgod, Sanjay, Sunder, V. Sham, Gouse, Sofia
Format Journal Article
LanguageEnglish
Published Bangalore Incessant Nature Science Publishers Private Limited 01.11.2016
Subjects
Cell adhesion & migration
Cell growth
Epidermal growth factor
Kinases
Mutation
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Summary:Odontogenic tumors (OT) encompass a diverse collection of lesions that ranges from hamartomas to benign and malignant neoplastic lesions of erratic aggressiveness. The progress and development of OT are influenced by variation of many kinds of genes and molecules. Genetic instability is a hallmark of cancer. This review illustrate a concurrent sketch of the recent updating of the molecular and genetic alterations linked with the growth and development of OT, including oncogenes, tumor-suppressor genes, oncoviruses, growth factors cell cycle regulators, apoptosis-related factors, regulators of tooth development, hard tissue-related proteins, cell adhesion molecules, matrixdegrading proteinases, factors of angiogenesis, and osteolytic cytokines. The logical and enhanced understanding of the molecular mechanism may provide newer thoughts for their recognition and administrate an improved prognosis of OT.
ISSN:2393-8625
2393-8625
DOI:10.15713/ins.jcri.140