The accuracies of DNA-based estimates of genetic merit derived from Angus or multibreed beef cattle training populations1,2,3

• Published in: Journal of animal science Vol. 90; no. 12; pp. 4191 - 4202
• Main Authors: Weber, K. L., Drake, D. J., Taylor, J. F., Garrick, D. J., Kuehn, L. A., Thallman, R. M., Schnabel, R. D., Snelling, W. M., Pollak, E. J., Van Eenennaam, A. L.
• Format: Journal Article
• Language: English
• Published: Champaign Oxford University Press 01.12.2012
• Subjects: Accuracy; Cattle; Genomics; Genotype & phenotype
• ISSN: 0021-8812; 1525-3163
• DOI: 10.2527/jas.2011-5020

Several organizations have developed prediction models for molecular breeding values (MBV) for quantitative growth and carcass traits in beef cattle using Bovine SNP50 genotypes and phenotypic or EBV data. Molecular breeding values for Angus cattle have been developed by IGENITY, Pfizer Animal Genetics, and a collaboration between researchers from Iowa State University and the University of Missouri-Columbia (ISU/UMC). The U.S. Meat Animal Research Center (USMARC; Clay Center, NE) has also developed MBV for 16 cattle breeds using 2 multibreed populations, the Germplasm Evaluation (GPE) Program and the 2,000 Bull Project (2K^sub ALL^), and 2 single breed subpopulations of the 2,000 Bull Project, Angus (2K^sub AN^) and Hereford (2K^sub HH^). In this study, these MBV were assessed relative to commercial ranch EBV estimated from the progeny phenotypes of Angus bulls naturally mated in multisire breeding pastures to commercial cows: 121 for USMARC MBV, 99 for ISU/UMC MBV, and 29 for IGENITY and Pfizer MBV (selected based on number of progeny carcass records). Five traits were analyzed: weaning weight (WW), HCW, marbling score (MS), rib-eye muscle area (RE), and, for IGENITY and Pfizer only, feedlot ADG. The average accuracies of MBV across traits were 0.38 ± 0.05 for IGENITY, 0.61 ± 0.12 for Pfizer, 0.46 ± 0.12 for ISU/UMC, 0.16 ± 0.04 for GPE, 0.26 ± 0.05 for 2K^sub ALL^, 0.24 ± 0.04 for 2K^sub AN^, and 0.02 ± 0.12 for 2K^sub HH^. Angus-based MBV (IGENITY, Pfizer, ISU/UMC, and 2K^sub AN^) explained larger proportions of genetic variance in this population than GPE, 2K^sub ALL^, or 2K^sub HH^ MBV for the same traits. In this data set, IGENITY, Pfizer, and ISU/UMC MBV were predictive of realized performance of progeny, and incorporation of that information into national genetic evaluations would be expected to improve EPD accuracy, particularly for young animals. [PUBLICATION ABSTRACT]