259 Association of rs 2781666 G/T polymorphism of arginase 1 gene with myocardial infarction in the Tunisian population
Arginase I (ARG I) is the final enzyme of the urea cycle that converts L-arginine to urea and ornithine. Emerging evidence have identified ARG I as a critical regulator for nitric oxide (NO) production via nitric oxide synthase (NOS). Therefore upregulation of ARG I inhibit NOS-mediated NO and may c...
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Published in | Archives of Cardiovascular Diseases Supplements Vol. 3; no. 1; p. 85 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Elsevier France
2011
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Online Access | Get full text |
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Summary: | Arginase I (ARG I) is the final enzyme of the urea cycle that converts L-arginine to urea and ornithine. Emerging evidence have identified ARG I as a critical regulator for nitric oxide (NO) production via nitric oxide synthase (NOS).
Therefore upregulation of ARG I inhibit NOS-mediated NO and may contribute to endothelial dysfunction. In addition, pathophysiological role of ARG I on vascular disease have been extensively documented, and some recent studies support a role for ARG I in the development and complications of coronary artery disease (CAD). The aim of the present study is to investigate the possible association between rs 2781666 G/T polymorphism of ARG I gene and myocardial infarction (MI) in the Tunisian population.
In a case-control study, a total of 321 patients with MI and 436 controls were included. The rs 2781666 G/T polymorphism of ARG I was determined by PCR-RFLP analysis.
Patients with MI had significantly higher frequency of TT genotype compared to controls (10.3% vs 6.7%; OR (95% CI), 2.05 (1.19 – 3.52), p = 0.009). The MI patients showed higher frequency of T allele compared to the controls (0.32 vs 0.23, OR (95% CI), 1.58(1.25 – 2.00), p<0.001). The association between rs 2781666 G/T polymorphism of ARG I gene and MI was no longer significant after adjustment for other well established risk factors.
Our results revealed a significant but not independent association between rs2781666 G/T polymorphism of ARG I gene and (MI) in the Tunisian population. |
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ISSN: | 1878-6480 |
DOI: | 10.1016/S1878-6480(11)70261-0 |