The recoverable isatin resin as a ligand for copper-type Ullmann C – N coupling reaction

The immobilization of isatin onto chloromethylated polystyrene resin as an efficient and recyclable ligand for promoting copper-catalyzed C – N coupling reactions was performed. With this ligand, a series of C – N coupling products between aryl halides and amines were synthesized in high yields unde...

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Bibliographic Details
Published inNew journal of chemistry Vol. 48; no. 31; pp. 14067 - 14070
Main Authors Zhao, Changxu, Shi, Xu, Zhang, Zhen, Wang, Jifan, Chen, Guoliang
Format Journal Article
LanguageEnglish
Published Cambridge Royal Society of Chemistry 05.08.2024
Subjects
Amines
Catalytic activity
Chemical activity
Chemical reactions
Chemical synthesis
Copper
Coupling
Halides
Ligands
Polystyrene resins
Substrates
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Summary:The immobilization of isatin onto chloromethylated polystyrene resin as an efficient and recyclable ligand for promoting copper-catalyzed C – N coupling reactions was performed. With this ligand, a series of C – N coupling products between aryl halides and amines were synthesized in high yields under mild conditions, and the ligand showed good substrate adaptability. The ligand is easy to recover and reuse without significantly reducing its catalytic activity. Therefore, many important organic structural units can be synthesized using this ligand in the chemical and pharmaceutical fields.
ISSN:1144-0546
1369-9261
DOI:10.1039/D4NJ01599A