Pd-Catalyzed cascade Heck cyclization/carbonylation of indoles with aryl formates: enantioselective construction of indolo[2,1- a ]isoquinolines

An efficient palladium-catalyzed cascade cyclization/carbonylation of indoles with aryl formates to access ester-functionalized indolo[2,1- a ]isoquinoline scaffolds has been developed. In addition, an asymmetric variant is also achieved using a chiral phosphine ligand, affording the indolo[2,1- a ]...

Full description

Saved in:
Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 60; no. 65; pp. 8613 - 8616
Main Authors Chi, Dongmei, Qi, Hongbo, Wang, Leming, Chen, Shufeng
Format Journal Article
LanguageEnglish
Published Cambridge Royal Society of Chemistry 09.08.2024
Subjects
Aromatic compounds
Carbonyls
Enantiomers
Formates
Indoles
Palladium
Phosphines
Online AccessGet full text

Cover

More Information
Summary:An efficient palladium-catalyzed cascade cyclization/carbonylation of indoles with aryl formates to access ester-functionalized indolo[2,1- a ]isoquinoline scaffolds has been developed. In addition, an asymmetric variant is also achieved using a chiral phosphine ligand, affording the indolo[2,1- a ]isoquinoline products in good yields and enantioselectivities.
ISSN:1359-7345
1364-548X
DOI:10.1039/D4CC02577F