Administration Of Hepatitis A Vaccine To A Military Population By Needle And

Military personnel are an important target population for hepatitis A immunization. Soldiers are often given vaccines by jet injector and may be required to receive multiple vaccines at one time. Formalin-inactivated hepatitis A vaccine containing 360 ELISA units of antigen was evaluated at Fort Cam...

Full description

Saved in:
Bibliographic Details
Published inThe Journal of infectious diseases Vol. 171; no. Supplement-1; pp. S53 - S60
Main Authors H. Hoke Jr, Charles, Egan, James E., Sjogren, Maria H., Sanchez, Jose, Defraites, Robert F., Macarthy, Philip O., Binn, Leonard N., Rice, Robert, Burke, Arlene, Hill, Jeffrey, Howard Kimes, M., Erikson, Loren, Boscia, Jerome, Moonsammy, George I., D'Hondt, Erik, Bancroft, And William H.
Format Journal Article
LanguageEnglish
Published The University of Chicago Press 01.03.1995
Online AccessGet full text

Cover

More Information
Summary:Military personnel are an important target population for hepatitis A immunization. Soldiers are often given vaccines by jet injector and may be required to receive multiple vaccines at one time. Formalin-inactivated hepatitis A vaccine containing 360 ELISA units of antigen was evaluated at Fort Campbell. Volunteers received vaccine at 0, 1, and 6 months as follows: group 1, hepatitis A vaccine by needle; group 2, hepatitis A vaccine by jet injector; group 3, hepatitis B vaccine by needle; and group 4, both hepatitis vaccines by needle in separate arms. Immune response and reactogenicity were evaluated. After two doses, recipients of vaccine administered by jet injector had a higher prevalence of antibody than those who received vaccine by needle (93% vs. 79%). By the 8th month, the vaccine was 100% immunogenic by either route or with hepatitis B vaccine. No interaction between hepatitis A and B vaccines was detected.
Bibliography:Reprints or correspondence: Dr. Charles H. Hoke, Jr., Dept. of Virus Diseases, Walter Reed Army Institute of Research, Washington, DC 203075100.
Present affiliations: Ogden Biosciences, Rockville. Maryland (R.R.); Walter Reed Army Medical Center, Washington, DC (M.H,S.); US Army Medical Research and Material Development Command (Provisional), Fort Detrick (W.H.B.); Colorado Springs. Colorado (A.B.); Louisiana State University Medical School, New Orleans (J.H.); Johns Hopkins University. Baltimore (L. E.).
istex:2CDC50C9E3897AE7D7B41C4328022C3A615B6E98
ark:/67375/HXZ-5RVXB4K8-V
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/171.Supplement_1.S53