Pyrexia of unknown origin: a rare presentation of primary ovarian lymphoma

It is very rare to have a lymphomatous involvement of ovary. Malignant lymphoma of ovary is a well-known late manifestation of disseminated nodal disease. Primary ovarian lymphoma with ovarian mass as an initial manifestation is a rare entity and may have varied presentations which can cause confusi...

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Bibliographic Details
Published inInternational Journal of Reproduction, Contraception, Obstetrics and Gynecology Vol. 9; no. 5; p. 2191
Main Authors Gokhale, Asha N, Agarwal, Akriti, Purandare, Bharat D
Format Journal Article
LanguageEnglish
Published International Journal of Reproduction, Contraception, Obstetrics and Gynecology 01.05.2020
Subjects
Cancer
Chemotherapy
Diagnosis
Health aspects
Histochemistry
Non-Hodgkin's lymphomas
Vincristine
Weight loss
Women
India
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Summary:It is very rare to have a lymphomatous involvement of ovary. Malignant lymphoma of ovary is a well-known late manifestation of disseminated nodal disease. Primary ovarian lymphoma with ovarian mass as an initial manifestation is a rare entity and may have varied presentations which can cause confusion to the physician and cause delay in diagnosis. Study presents a case of non-Hodgkin's lymphoma where the initial presentation was fever with weight loss, and was evaluated as pyrexia of unknown origin. When no other cause of fever was identified PET-CT was done showing metabolically active uterine mass with no lymphadenopathy. Exploratory laparotomy was planned followed by hysterectomy with bilateral salpingo ophorectomy with omentectomy. Ovarian malignancy was detected intraoperatively, which was diagnosed as diffuse large B cell lymphoma, NHL double expresser phenotype on histopathology and IHC. Patient was started on chemotherapy and is doing fine. Keywords: Diffuse large B cell lymphoma, Primary ovarian lymphoma, Pyrexia of unknown origin
ISSN:2320-1770
2320-1789
DOI:10.18203/2320-1770.ijrcog20201834