Effect of Simultaneous Intake of Medium-Chain Triglyceride and d-Allulose on Body Fat Accumulation in Rats Fed a High-Fat Diet

• Published in: Current topics in nutraceuticals research Vol. 21; no. 3; pp. 242 - 247
• Main Authors: Matsuo, Tatsuhiro, Yokoyama, Chihiro, Yamada, Takako, Iida, Tetsuo, Mochizuki, Susumu, Yoshihara, Akihide, Akimitsu, Kazuya
• Format: Journal Article
• Language: English
• Published: New Century Health Publishers, LLC 01.08.2023
• Subjects: Dietary supplements; Fatty acids; Fructose; Triglycerides; Japan
• ISSN: 1540-7535; 2641-452X
• DOI: 10.37290/ctnr2641-452X.21:242-247

Medium-chain triglycerides, lipids containing three 6-12 carbon medium-chain fatty acids, have antiobesity effects because they do not promote lipogenesis. D-Allulose, a low-calorie epimer of fructose commercially used as a low-calorie sweetener, suppresses hepatic lipogenesis and enhances postprandial fat oxidation. Therefore, we have explored whether a simultaneous intake of medium-chain fatty acids and D-allulose may exhibit a greater reduction in de novo lipogenesis and increase their antiobesity effects. To this end, 32 male Wistar rats were divided into four treatment groups of equal sizes: control, 3% D-allulose-treated, 5% medium-chain triglycerides-treated, and 3% D-allulose + 5% medium-chain triglycerides-treated. After 8 weeks of ad libitum exposure to these diets, D-allulose significantly decreased intra-abdominal adipose tissue and total body fat weight, with or without medium-chain triglyceride supplementation. The antiobesity effect of D-allulose was observed with or without dietary medium-chain triglyceride supplementation in high-fat diet-induced obese rats, but no synergistic effect was detected between D-allulose and medium-chain triglycerides. Keywords: Body fat, D-allulose, Medium-chain triglyceride, Rat